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White Papers

Our published research and technical documentation.

Digital Twin Architectures for Biological Systems

A comprehensive framework for constructing high-fidelity virtual representations of cellular and organ-level biological environments using AI-driven simulation engines.

Nature Computational Science
VARL·January 2026·42 pages
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AI-Integrated Drug Discovery: From Molecule to Treatment in Under 3 Years

How VARL's computational pipeline compresses traditional drug development timelines by replacing sequential laboratory testing with parallel digital twin simulations.

Cell Reports Methods
VARL·December 2025·38 pages
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Protein Interaction Networks as Computational Graphs

Mapping the human interactome as a dynamic graph structure enables real-time pathway analysis and reveals intervention points invisible to traditional methods.

Science Advances
VARL·November 2025·31 pages
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Precision Agriculture Through Molecular Simulation

Applying digital twin technology to crop systems: predicting stress responses, optimizing nutrient uptake, and designing climate-resilient varieties at the molecular level.

Nature Food
VARL·October 2025·36 pages
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Continuous Biomarker Monitoring with AI-Powered Sensor Arrays

A new paradigm for early disease detection: tracking hundreds of molecular markers simultaneously to identify disease trajectories before clinical symptoms emerge.

The Lancet Digital Health
VARL·September 2025·29 pages
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The Compounding Intelligence Model: Why Discovery Accelerates Exponentially

Every experiment VARL runs makes the next one faster. This paper formalizes the feedback architecture that turns biological research into a self-improving system.

Nature Machine Intelligence
VARL·August 2025·24 pages
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Lipid Nanoparticle Optimization via Reinforcement Learning

Training RL agents to design lipid nanoparticle formulations that maximize cellular uptake while minimizing off-target effects, achieving 4x improvement over conventional screening.

ACS Nano
VARL·July 2025·33 pages
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Cross-Species Immune Response Modeling

Building transferable immune system models across mammals to accelerate vaccine development and predict autoimmune cascade failures before they manifest clinically.

Nature Immunology
VARL·June 2025·41 pages
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